Relationship between serum uric acid and estimated glomerular filtration rate in adolescents aged 12-19 years with different body mass indices: a cross-sectional study

Background Globally, chronic kidney disease (CKD) is a growing public health concern. Serum uric acid (SUA) an easily detectable and readily available biochemical indicator that has long been recognized as independent risk factor for CKD. In addition, studies have indicated potential relationship between SUA body mass index (BMI). However, on the effect of levels estimated glomerular filtration rate (eGFR) in adolescents with different BMIs are very rare. Methods Weighted multiple regression analysis was used to estimate log-transformed eGFR. Additionally, we weighted generalized additive model smooth curve fitting describe nonlinear relationships subgroup analysis. Results First, negatively associated eGFR even after adjusting all covariates (β=-0.0177, 95% CI: -0.0203-0.0151, P<0.0001). Second, results stratified found covariates, decrease due changes per (Per 1, mg/dL increase) elevated female -0.0216, -0.0138, P<0.0001), aged 12-15 years (β=-0.0163, -0.0200, -0.0125, P<0.0001) black (β=-0.0199, -0.0251, -0.0148, adolescents. Furthermore, higher BMI had levels, significantly underweight (β=-0.0386, (-0.0550, -0.0223), Conclusion 12-19 years. first time affects differently BMIs. This particularly significant